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First, the optimization of the Nrf2 pathway through targeted drug delivery, e.g., lipid nanoparticles (LPNs) loaded with sulforaphane or bardoxolone methyl could enhance endothelial uptake while avoiding systemic side effects (Zhang et al., 2024), and LNPs conjugated to VCAM-1 antibodies for inflamed vasculature targeting (Smith et al., 2021)

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Genetic predisposition does not predict exact acetaminophen response or toxicity risk, but rather indicates which metabolic pathways may function differently in your body